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Literature summary for 7.2.2.3 extracted from

  • Saraiva, V.B.; Wengert, M.; Gomes-Quintana, E.; Heise, N.; Caruso-Neves, C.
    Na(+)-ATPase and protein kinase C are targets to 1-O-hexadecylphosphocoline (miltefosine) in Trypanosoma cruzi (2009), Arch. Biochem. Biophys., 481, 65-71.
    View publication on PubMed
Search for more literature for 7.2.2.3

Activating Compound

Activating Compound Comment Organism Structure
Ca2+ 67% activity after addition of EGTA Trypanosoma cruzi
Na+
-
 Trypanosoma cruzi

Inhibitors

Inhibitors Comment Organism Structure
Furosemide completely inhibited by 2 mM Trypanosoma cruzi
miltefosine 1-O-hexadecylphosphocholine Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
 Y-strain
-
Trypanosoma cruzi Y-
-
 Y-strain
-

Source Tissue

Source Tissue Comment Organism Textmining
epimastigote
-
 Trypanosoma cruzi
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in
-
 Trypanosoma cruzi ADP + phosphate + Na+/out
-
 ?
ATP + H2O + Na+/in
-
 Trypanosoma cruzi Y- ADP + phosphate + Na+/out
-
 ?

Synonyms

Synonyms Comment Organism
Na+-ATPase
-
 Trypanosoma cruzi

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
 Trypanosoma cruzi

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.044
-
-
 Trypanosoma cruzi miltefosine
0.22
-
 in homogenate of clone CL14 Trypanosoma cruzi Furosemide